Abazalwane benza inqubo ye-alchemic evinjelwe yokushintshwa komuntu ngomzamo wokumvusa lapho uTrisha ebulawa isifo. Ngenxa yalokhu, ukubuyela emuva kwe-transmutation futhi emthethweni ngokushintshana okulinganayo, umlenze wesobunxele nomzimba wonke ka-Alphonse ka-Edward konakele. U-Edward ulahlekelwa yingalo yakhe yangakwesokudla ukuze asindise umphefumulo ka-Alphonse, ewubopha unophawu lwegazi esembathweni sezembatho zempi. URoy Mustang umema u-Edward ukuthi abe yindlela yokubuyisa umzimba ka-Alphonse ozocwaningwa yi-State Alchemist. U-Edward unqoba, eba igama ngokwamalungu akhe okufakelwa, i-Fullmetal Alchemist.
Eminyakeni emithathu kuqhubeke, ama-Elrics athungatha itshe lefilosofi likaHulumeni ukuze afeze izinhloso zawo. UMarcoh uthumela amanothi akhe ukuthi atholakale kubo, kepha bafunda into ebalulekile yokwenza itshe kube imihlatshelo yabantu. Umngani kaMustang, uMaes Hughes, uqhubeka nocwaningo lwabo, kepha udutshulwe wabulawa ngomona ofihliwe wokuthola amasu eHomunculi.
Ngokubona no-Izumi, ama-Elric afunda ukushintshwa komuntu kwenziwa nguye enganeni yakhe ezelwe ishonile. I-homunculus Greed enobudlova ibamba u-Alphonse, kepha isindiswa ngumongameli ka-Amestris u-King Bradley, okhonjiswe ukuthi usebenza njenge-homunculus Wrath. Ngakho-ke ukuhaha kuncibilikiswa ngaphakathi bese kuphinda kufakwe kabusha ngaphakathi kukasunguli uYise kaHomunculi. UWinry nama-Elrics babuyela eCentral City ukuya kuHughes kodwa bezwa ngokudlula kwakhe emhlabeni. ULieutenant Maria Ross wakhelwe ukubulala uHughes, kodwa ngokusobala ubulawa nguMustang. Kodwa-ke, u-Edward ufunda ukuthi ukuhamba kukaRoss kwahlelwa ukuze ashushumbiswe nguMustang esuka e-united ukuya eXing, esizwa yinkosana uXingese uLing Yao. UHohenheim uphinde wahlangana no-Edward kodwa uyamdelela ngokungabi bikho kwakhe isikhathi eside lapho ehlala khona.
Njengoba ukulandisa kuqhubeka, amaHomunculi ahlangana nabaphikisi kaninginingi. I-Mustang ibulala inkanuko; UMustang noLing bathatha i-Gluttony, kepha-ke ugcina esedla umona ku-null yakhe, no-Edward, isisu esifana neLing. U-Gluttony uthatha u-Alphonse ukuyohlangana noBaba, kepha u-Ling uphendukela ku-homunculus, ikakhulukazi i-avatar entsha ye-Greed, lapho abanye beqa esiswini se-Gluttony. Ama-Elrics ayadedelwa ukuze aqhubeke nokulandela lokho inqobo nje uma ubaba engaphikiswa yibo.
Ukuthola umhubhe ongaphansi komhlaba ngaphansi kukaBriggs, uGeneral Olivier Armstrong uthola uBaba nama-Elrics bekade besungula iqembu likazwelonke lokushintshana futhi lihlose ukunikeza izakhamizi zalo ukuze likwazi ukukhuphukela ebunkulunkulwini. Ukuhaha kuyalulama kukhaphela uBaba nezinkumbulo zakhe zangaphambili, ehlangana ngemuva, no-Edward, amanxusa e-chimera kaKimblee Hohenheim. UHohenheim udalula amadodana akhe ngamanye ukuthi akayona inyama, waphenduka waba yitshe lefilosofi eliphilayo likaBaba eminyakeni engamakhulu amane emuva.
Usuku lweSithembiso luyafika futhi uBaba ulungiselela ukuqala isu lakhe lokuba nokusitheka kwelanga nalabo abazame ukuthunyelwa kwabantu njengemihlatshelo yakhe ebalulekile. Abaphikisi abahlukahlukene baphikisana nabangane bakaBaba, ngakho konke ukuphelelwa yisikhathi kukaHomunculi. Ukulandela i-Mustang ephoqelelwe, kanye nama-Elrics, Izumi, Hohenheim aqoqwa njengezimbangela zikababa ezenza ukuthi kube nokushintshwa kukazwelonke. Yize kunjalo, uScar noHohenheim benza ukuthi ama-Amestria asindiswe ngezinyathelo zokuphikisa. Ukuhaha konakaliswa nguBaba, yize ubaba ebhekene nenhla engenhla lapho abalingisi abaphambili balwa naye ukuze bacekele phansi itshe lakhe lefilosofi.
U-Alphonse, izikhali zakhe esezonakele ngempi yokugcina ebhekene noBaba, unikeza umoya wakhe ukuthi abuyise ingalo yangakwesokudla, yona yona echitha itshe likaBaba, imbuyisela emuva eSangweni Lamaqiniso Lika-Edward. U-Edward ulahlekelwa amandla akhe okwenza i-alchemy ukuze alulame umphefumulo nomzimba ka-Alphonse. UHohenheim ubona ithuna lapho efa khona enezinwele zikaTrisha.
