Eminyakeni eyisikhombisa edlule, abazali baka-Yuto Amakawa bashona engozini yemoto, bamshiya yedwa engasenalutho olusele ekhaya, isihlobo esisodwa sasiyi-amulet engaqondakali futhi engavamile ayinikwa ugogo wakhe ongasekho. Kusukela ngaleso sikhathi, umngane wakhe wobuntwana u-Rinko Kuzaki (kanye nabazali bakhe[isahluko 1]) ubemphekela futhi emnakekela. Lapho ehlangana nedemoni lekati lowesifazane we-samurai, u-Himari impilo yakhe ishintsha kakhulu. U-Himari udalula kuye ukuthi idlanzana lokhokho bakhe laliyingxenye yemindeni eyishumi nambili yeDemon Slayer eyayibulala amademoni ngenxa yenkathi yokubusa. Ufunge isifungo sokuvikela u-Yuto kumadeveli azimisele ngokumbhubhisa, kodwa ukungezwani namakati e-Yuto kwenza kube nzima ukumnakekela.
Kamuva, uYuto uwela phezu kwabesifazane abahlukahlukene abamthanda: Shizuku, mizuchi esebenzisa ingane encane; uLizlet, i-tsukumogami esebenzisa incekukazi enamabele ephakela itiye; kanye no-Kuesu, omunye Umbulali Wedemoni ovezwe ukuthi uyingoduso ka-Yuto kanye nendoda yase-Yuto elahlekile.
Njengoba umbukiso uqhubeka, iqembu kanye no-Yuto bawela phezu kwe-ayakashi ethile enamandla, abambalwa babo bengabambisene, futhi u-Yuto ekugcineni wenza ukukhetha okushintsha ukuphila ukuze alwe ngenxa yombono wakhe wokuphilisana phakathi kwe-ayakashi nomuntu ngamunye.
